Figure 3.
Plasma ACTH, CORT and BAL responses after i.p. EtOH (4g/kg) injection in male Avpr1b KO and wild-type mice. Values are mean ± SEM, n = 4-6 mice/group. A = plasma ACTH levels. a, P < 0.0001 EtOH wild-type vs. vehicle (veh) wild-type; b, P < 0.001 EtOH wild-type vs. EtOH KO; c, P < 0.05 EtOH KO vs. vehicle KO. B = plasma CORT levels. a, P < 0.0001 EtOH wild-type vs. vehicle wild-type; b, P < 0.001 EtOH wild-type vs. EtOH KO; EtOH KO vs. vehicle KO. There is no significant difference between vehicle wild-type and vehicle KO plasma ACTH or CORT levels. C = blood alcohol levels (BALs). a, P < 0.0001 EtOH vs. vehicle of both genotypes.; ND, not detectable. There is no significant difference between EtOH wild-type and EtOH KO plasma BALs.