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Percentage change in epicardial coronary diameter with bradykinin in the proximal and the distal segments before (empty circles) and after (filled circles) NG-monomethyl-L-arginine (L-NMMA) infusion. Although bradykinin induced epicardial coronary vasodilatation in a dose dependent manner, the dilator effects were significantly attenuated after L-NMMA infusion in the proximal and distal segments (p < 0.001 for both).
