Figure 2  .

Extracellular, membrane and intracellular control points for cell division, showing some of the protein interactions where gene therapy might act. bFGF, basic fibroblast growth factor; Cdks, cyclin dependent kinases; gax, growth arrest homeobox; M, mitosis; PCNA, peripheral cell nuclear antigen; RB, retinoblastoma protein; S, DNA synthesis; sdi 1, senescent cell derived inhibitor 1; TK, thymidine kinase; TGF-β1, transforming growth factor β1; VEGF, vascular endothelial derived growth factor; PDGF, platelet derived growth factor; cip 1, Cdk interacting protein; ODC, ornithin olecarboxylase; NMMHC II B, non-muscle myosin heavy chain II B; waf 1, wild-type p53 activated fragment.