Table 1.
Carboxyhemoglobin (COHb) Levels in Mice Exposed to Hyperoxia in the Presence and Absence of CO
| Treatment group | COHb (24 hours) | COHb (72 hours) |
|---|---|---|
| Air | 4.1 ± 0.4 | 2.5 ± 0.5 |
| CO | 35 ± 2* | 31.6 ± 4* |
| O2 | 4.1 ± 0.5 | 2.2 ± 1 |
| CO/O2 | 14 ± 1† | 10.7 ± 0.8† |
*P < 0.001 vs. air and O2-exposed mice.
†P < 0.01 vs. CO alone treated mice.
Effects of CO (250 ppm) exposure on carboxyhemoglobin levels in mice in the presence and absence of 98% O2. A blood sample was taken at 24 hours and again at 70 hours of exposure and analyzed for COHb by a co-oximeter. Data represent mean ± SD of 4 animals/group.