Table 2.
Carbon Monoxide Reduces Markers of Inflammation in the Lung
| Treatment | Cells/ml × 106 | Wet/dry | MDA (nmol/mg) | |
|---|---|---|---|---|
| WBC | Mono | |||
| Air | 3.72 ± 0.60 | 3.71 ± 0.26 | 4.55 ± 0.01 | 0.45 ± 0.03 |
| CO | 3.55 ± 0.25 | 3.33 ± 0.24 | 4.54 ± 0.01 | 0.52 ± 0.01 |
| O2 | 8.89 ± 0.95* | 8.20 ± 1.06* | 7.14 ± 0.03* | 0.64 ± 0.05† |
| CO/O2 | 3.95 ± 0.56 | 3.74 ± 0.55 | 5.52 ± 0.04‡ | 0.47 ± 0.05 |
*P < 0.001 vs. air, CO, CO/O2.
†P < 0.03 vs. air, CO.
‡P < 0.02 vs. air, CO/O2.
Effects of CO (250 ppm) on hyperoxia-induced lung injury parameters. Mice were exposed continuously to >98% O2 in the presence or absence of CO. At 84 hours of exposure one group of animals was lavaged and cellular profiles and protein contents of the lavagates were determined. The lungs of a second group of mice were extracted and analyzed for wet/dry ratio and lipid peroxidation. Control animals were exposed either air or CO for 84 hours in identical exposure chambers. Values represent the mean ± SE of 4 to 12 animals per group.