Table 3.
Immunohistochemical and in Situ Hybridization Findings from Cynomolgus Monkeys Infected with Ebola Virus
| Animal number | Days P.I. | Lymph nodes | Spleen | Liver/adrenal | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mono | Mac | DC | Mono | Mac | DC | Kup | Hep | Cort | ||
| CQ9877 | 1 | − | − | − | − | − | − | − | − | − |
| CQ9890 | 1 | − | − | − | − | − | − | − | − | − |
| 0717CQ | 1 | − | − | − | − | − | − | − | − | − |
| CQ9846 | 2 | − | − | − | − | −* | − | − | − | − |
| 0331CQ | 2 | − | − | − | −* | − | − | − | − | − |
| CQ9028 | 2 | − | −* | − | − | −* | − | −* | − | − |
| 32Q | 3 | − | − | − | − | ++ | ++ | ++ | − | − |
| CQ8667 | 3 | + | + | + | ++ | ++ | ++ | ++ | − | − |
| CQ9093 | 3 | − | − | − | − | ++ | ++ | ++ | − | − |
| CQ8681 | 3 | − | − | − | − | ++ | ++ | ++ | − | − |
| 28–427 | 4 | − | − | − | − | ++ | ++ | ++ | − | − |
| CQ9887 | 4 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | + | − |
| CQ9108 | 4 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | − | − |
| CQ9095 | 4 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | + | − |
| 28–221 | 5 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| 0359CQ | 5 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| 0323CQ | 5 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| 48–143 | 5 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| CQ9878 | 6 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| 28–332 | 6 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
| CQ9112 | 6 | +++ | +++ | +++ | +++ | +++ | +++ | +++ | ++ | ++ |
+, EBOV RNA- and antigen-positive cells were rarely detected; ++, EBOV-positive cells were occasionally detected; +++, EBOV-positive cells were frequently detected; −, no EBOV-positive cells were detected.
*, EBOV RNA was detected in cells that were negative for EBOV antigen.
Mono, monocytes; Mac, macrophages; DC, dendritic cells; Kup, Kupffer cells; Hep, hepatocytes; Cort, adrenal cortical cells.