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TIMP activity in response to cigarette smoke: evidence for NE-mediated TIMP degradation. Perfused whole lung extracts were subjected to reverse zymography. Protection from proteolytic activity is indicated by presence of gelatin (dark bands) at molecular migration of TIMPs on the blot. Note the presence of larger amounts of a 27.5-kd inhibitor, TIMP-1, in mice lacking NE. Again, each lane represents equally pooled samples from three lungs of the given genotype and exposure.
