Table 1.
Air-Space Enlargement in Response to Cigarette Smoke Exposure
| Group | n | CL* (S.E.) | % Increase with Sm | P value (vs NS) | P value (vs WT Sm) |
|---|---|---|---|---|---|
| WT (NS) | 24 | 30.2 (0.5) | — | — | <0.0001 |
| WT (Sm) | 19 | 36.8 (0.8) | 22 | <0.0001 | — |
| NE−/− (NS) | 14 | 30.4 (0.5) | — | — | |
| NE−/− (Sm) | 26 | 33.0 (0.6) | 9 | (0.1) | 0.002 |
| MMP-12−/− (NS) | 12 | 29.9 (0.4) | — | — | |
| MMP-12−/− (Sm) | 12 | 29.8 (0.5) | 0 | (0.5) | 0.001 |
*Chord Length (CL) measures alveolar diameter. Values shown are the mean and standard error (in parentheses). Groups of mice, with the number of mice in each group identified (n), were either non-smoke-exposed (NS) or exposed to cigarette smoke (Sm). Wild-type mice (WT) were 129/SvXC57BL/6, the background of both mutant genotypes. P values comparing different groups were derived from two-tailed Student’s t-test.