Table 3.
Selected Differentially Expressed Genes in the Baboon Model of ALD
| Genes | GenBank ID | Mean expression ratio |
|---|---|---|
| Fibrosis/ECM | ||
| Annexin II (ANX2); lipocortin II; calpactin I heavy subunit | D00017 | 5.1 |
| Astrocyte glial fibrillary acidic protein (GFAP) | J04569 | 1.8 |
| Calgizzarin; S-100 calcium-binding protein A11 (S100A11) protein | D38583 | 1.7 |
| Calpactin I light chain; annexin II ligand | M81457 | 1.6 |
| Follistatin 1 and 2 (FS) (Activin-binding protein) | M19481 | 1.5 |
| PLA2; phospholipase A2*† | M86400 | 1.7 |
| Plasminogen precursor (PLG) | X05199 | 1.5 |
| Platelet-derived growth factor (PDGF) receptor beta-like tumor suppressor (PRLTS) | D37965 | 2.6 |
| Immune | ||
| Annexin XI (Calcyclin-associated annexin 50) (CAP-50) | L19605 | 1.5 |
| CCL2; monocyte chemotactic protein 1 (MCP1) | M24545 | 1.5 |
| CD11a; integrin alpha L (ITGAL) | Y00796 | 2.5 |
| CD80; CD28 ligand; T-lymphocyte activation CD80 antigen | M27533 | 1.9 |
| Complement 3 (C3)*‡ | K02765 | 6.5 |
| CXCL10; IP10; interferon gamma-induced protein; SCYB10 | X02530 | 2.2 |
| Granulocyte colony-stimulating factor (G-CSF); pluripoietin | X03438 | 1.8 |
| Lipopolysaccharide-binding protein (LBP) | M35533 | 2.2 |
| Trafficking | ||
| Annexin I (ANX1) | X05908 | 2.0 |
| Cellular retinol-binding protein I (RBP1; CRBP1) | M11433 | 1.5 |
| Clathrin assembly protein lymphoid myeloid leukemia (CALM) | U45976 | 1.8 |
| Clathrin coat assembly protein AP50; KIAA0109 | D63475 | 1.8 |
| Clathrin heavy subunit 1 (CLH-17); KIAA0034 | D21260 | 1.9 |
| Clathrin light chain A (Brain and Lymphocyte LCA) | M20472 | 1.8 |
| EDF-1 protein | D63475 | 2.4 |
| Lysosomal protective protein; cathepsin A; carboxypeptidase C; PPGB | M22960 | 1.6 |
| Metabolism | ||
| Known alcohol metabolism enzymes | ||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase; HMGCR) | M11058 | 1.6 |
| Alcohol dehydrogenase alpha subunit *§ | M12271 | 7.4 |
| Aldehyde dehydrogenase (ALDH6) | U07919 | 1.7 |
| Aldehyde dehydrogenase 5 (ALDH5; ALDHx) | M63967 | 1.5 |
| Cytochrome P450 IIE1 (CYP2E1) | J02625 | 2.8 |
| Cytochrome P450 IIIA3 (CYP3A3)*¶ | M13785 | 3.8 |
| Glutathione peroxidase (GSHPX1; GPX1)*∥ | Y00483 | 2.0 |
| Glutathione S-transferase A1 (GTH1; GSTA1); HA subunit 1; GST-epsilon** | M25627 | 2.1 |
| Other metabolism genes | ||
| Apolipoprotein E (APOE) | M12529 | 2.5 |
| Cholesteryl ester transfer protein (CETP); lipid transfer protein I | M30185 | 1.7 |
| Cytochrome c oxidase polypeptide Vb (COX5B), mitochondrial*†† | M19961 | 2.2 |
| Cytoplasmic hydroxymethylglutaryl-CoA synthase | X66435 | 1.8 |
| Hepatic triglyceride lipase (HTGL) | X07228 | 2.6 |
| Hydroxyacyl-CoA dehydrogenase; 3-ketoacyl-CoA thiolase; enoyl-CoA hydratase beta subunit | D16481 | 1.7 |
| Mitochondrial acetyl-CoA acetyltransferase | D90228 | 2.9 |
| Mitochondrial ATP synthase alpha chain; (ATP5A1; ATPM; hATP1) ATP5A1 | D14710 | 3.0 |
| Mitochondrial hydroxymethylglutaryl-CoA synthase | X83618 | 2.7 |
| NADH-cytochrome B5 reductase | Y09501 | 1.6 |
| Cell signaling | ||
| Calmodulin | M27319 | 1.6 |
| Calmodulin-related protein NB-1; calmodulin-like protein (CLP) | M58026 | 1.6 |
| Stress | ||
| C-reactive protein | X56692 | 2.0 |
| MT1H (Methallothionein-IH)*‡‡ | X64177 | 0.5 |
| Protein synthesis/degradation | ||
| 23-kDa highly basic protein; 60S ribosomal protein L13A (RPL13A)*§§ | X56932 | 2.3 |
| DNA-directed RNA polymerase II 14.4-kDa polypeptide; RPB6*¶¶ | Z27113 | 1.7 |
*Upregulated isoforms/family members of the gene.
†Lysosomal phospholipase A2; membrane-associated phospholipase A2;PLA2G2A; PLA2B; RASFA.
‡Complement component 1r (C1R); complement component 1s (C1S); Complement factor B.
§Alcohol dehydrogenase2; alcohol dehydrogenase 3.
¶CYP3A4; CYP3A5; CYP3A7; CYP51 + CYP51P1 + CYP51P2; CYP1A1 + CYP1A2; CYP2B6 + CYP2B3; CYP4A11; CYP4B1; CYP4F2 + CYP4F3; CYP7A1; CYP17A1; CYP27A.
∥Plasma glutathione peroxidase (GPXP; GPX3); GSHPX-GI; glutathione peroxidase-related protein 2 (GPRP).
**Glutathione S-transferase Mu 5 (GSTM5-5) (GST Class-MU).
††Cytochrome c oxidase (COX) polypeptide VIb (COX6B); COX6C; COX7A, liver; COX7C; COX8, liver/heart.
‡‡Metallothionein isoform 1L (MT-1L) + metallothionein isoform 1R + MT2 (methallothionein-II); metallothinein-0,
§§40S ribosomal protein S9; 60S Acidic ribosomal protein P1; 60S ribosomal protein L14 (RPL14); CAG-ISL 7; 60S ribosomal protein L22 (RPL22); 60S ribosomal protein L37 (RPL37).
¶¶DNA directed RNA polymerase II 14.5-kDa polypeptide; RPB9; RPB14.5; DNA-directed RNA polymerase II 23 KD polypeptide (RPB25) (XAP4) (RPB5).