Table 5.
Differentially Expressed Genes Common in Both the Baboon Model and Human ALD
| Gene | Category | Mean expression ratio | |
|---|---|---|---|
| Baboon | Human | ||
| (A) Genes up-regulated in both baboon and human | |||
| 14-3-3 Protein zeta/delta (PKC inhibitor protein-1) | Immune | 1.5 | 2.6 |
| Adipophilin | Metabolism | 1.6 | 2.5 |
| Aortic carboxypeptidase-like protein ACLP (AEBP1) | Trafficking | 1.6 | 5.7 |
| Alpha-2-HS-glycoprotein alpha and beta chain | Fibrosis/ECM | 2.1 | 2.2 |
| Annexin I (lipocortin I) | Trafficking | 2.0 | 4.7 |
| Calgizzarin; S-100 calcium-binding protein A11 (S100A11) protein | Fibrosis/ECM | 1.5 | 2.7 |
| Calpain 2 large (catalytic) subunit; M-type calcium-activated neutral proteinase (CANP) | Fibrosis/ECM | 1.5 | 2.8 |
| Carbamoyl-phosphate synthetase 1, mitochondrial | Metabolism | 1.5 | 2.9 |
| CCL2; monocyte chemotactic protein 1 (MCP1) | Immune | 1.6 | 3.0 |
| Coagulation factor II (thrombin) receptor | Fibrosis/ECM | 1.5 | 2.3 |
| Cytochrome P450, subfamily IIIA, polypeptide 7 (CYP3A7) | Metabolism | 2.7 | 4.5 |
| Guanine nucleotide binding protein; transducin beta-1 subunit | Signaling | 2.3 | 2.7 |
| Inhibitor of DNA binding 3 (HLH1R2) | Transcription/Nuclear | 2.4 | 2.5 |
| Lumican | Fibrosis/ECM | 2.3 | 6.8 |
| Matrix gla-protein (MGP) | Fibrosis/ECM | 3.6 | 4.9 |
| Msg1-related gene 1 (mrg1) | Signaling | 1.7 | 3.8 |
| Phospholipase A2 (PLA2) | Fibrosis/ECM | 1.5 | 2.6 |
| Regulator of g-protein signaling 5 (RGS5) (RGP5) | Signaling | 1.5 | 3.4 |
| Thymosin beta 4; FX | Fibrosis/ECM | 1.8 | 2.3 |
| Thymosin beta-10 (TMSB10; THYB10); PTMB10 | Fibrosis/ECM | 1.9 | 2.4 |
| (B) Genes downregulated in both baboon and human | |||
| Glutaredoxin (thioltransferase) | Stress | 0.5 | 0.5 |
| MT-1L (methallothionein-IL) | Stress | 0.5 | 0.3 |
| Superoxide dismutase 1 (SOD1) | Stress | 0.5 | 0.5 |
| (C) Genes discordant in the two species | |||
| C-reactive protein | Immune | 1.8 | 0.2 |
| Cytochrome P450 IIE1 (CYP2E1) | Metabolism | 1.9 | 0.7 |
| farnesyl pyrophosphate synthetase | Metabolism | 2.8 | 0.5 |
| Hepatocyte growth factor-like protein; macrophage-stimulating protein (MSP) | Immune | 1.5 | 0.5 |
| Lipopolysaccharide-binding protein (LBP) | Immune | 1.8 | 0.3 |