Table 2.
Expression Pattern of Ep-CAM in Normal Tissue, Dysplasia, and Carcinoma (ca)
| Epithelium (species) | Antibody | Expression pattern Ep-CAM | ||
|---|---|---|---|---|
| Normal tissue | Premalignant | Carcinoma | ||
| Oral mucosa, glottic squamous epithelium | KS1/4 | Negative | Dysplasia: | Positive |
| 323/A3 | Positive | positive | Positive | |
| Esophagus | KS-1 | Negative (columnar cells) | Metaplasia: positive (BE) | |
| Negative (squamous) | ||||
| Gastric | 323/A3 | Positive only in crypts | Positive constitutive from crypts till villae | |
| Negative (mucosa) | ||||
| Colon | KS1/4 | Positive | Adenomas: enhanced | Enhanced (colorectal ca) |
| 323/A3 | ||||
| Liver | 323/A3 | Negative | Positive | Positive (CHC) |
| 17-1A | Positive (regenerating/Proliferating hepatocytes) | Negative (HCC) | ||
| MOC31 | ||||
| Ber-EP4 | ||||
| Pancreas | KS1/4 | Positive | Enhanced | |
| Kidney | Ber-EP4 | Positive* | Heterogeneous (clear cell ca) | |
| FU-MK-1 | ||||
| Bladder | AUA1 | Positive | Enhanced | |
| FU-MK-1 | ||||
| Testes | HEA125 | Positive* | Positive* | |
| Prostate | 323/A3 | Positive | Enhanced | |
| FU-MK-1 | ||||
| Mammary | 2G8 | Positive | Enhanced | |
| ESA | ||||
| 323/A3 | ||||
| 17-1A | ||||
| Ovary | AUA-1 | Low-positive (oocyte) | Enhanced (serous) | |
| Ber-EP4 | Enhanced (mucinous) | |||
| Uterine cervix | 323/A3 | Negative | Dysplasia: positive | Positive |
| Lung | Ber-EP4 | Low positive | Positive (SCC) | |
| Negative (mesothelioma) | ||||
| Lymph node metastasis from NSCLC: positive | ||||
| Skin | Ber-EP4 | Negative (squamous) | Positive (BCC) | |
| MH99 | Positive (sweat ducts/ | Positive (basosquamous) | ||
| Proliferating squamous cells) | Negative (SCC) | |||
*For details on cell types and tumor types: see text.