Table 1.
Immunohistochemical and in Situ Hybridization Findings from Endothelial Cells of Cynomolgus Monkeys Infected with Ebola Virus
| Animal number | Days P.I. | HEV | Sin | Spl | Lam prop | Ren cap | Alv cap | Heart | Brach plex | Brain |
|---|---|---|---|---|---|---|---|---|---|---|
| CQ9877 | 1 | − | − | − | − | − | − | − | − | − |
| CQ9890 | 1 | − | − | − | − | − | − | − | − | − |
| 0717CQ | 1 | − | − | − | − | − | − | − | − | − |
| CQ9846 | 2 | − | − | − | − | − | − | − | − | − |
| 0331CQ | 2 | − | − | − | − | − | − | − | − | − |
| CQ9028 | 2 | − | − | − | − | − | − | − | − | − |
| 32Q | 3 | − | − | − | − | − | − | − | − | − |
| CQ8667 | 3 | − | − | − | − | − | − | − | − | − |
| CQ9093 | 3 | − | − | − | − | − | − | − | − | − |
| CQ8681 | 3 | − | − | − | − | − | − | − | − | − |
| 28-427 | 4 | − | − | − | − | − | − | − | − | − |
| CQ9887 | 4 | − | + | − | − | − | − | − | − | − |
| CQ9108 | 4 | − | + | − | − | − | − | − | − | − |
| CQ9095 | 4 | + | + | − | − | − | − | − | − | − |
| 28-221 | 5 | ++ | ++ | + | + | + | − | − | + | − |
| 0359CQ | 5 | + | ++ | + | + | + | − | − | − | − |
| 0323CQ | 5 | ++ | ++ | + | + | + | + | − | + | − |
| 48-143 | 5 | ++ | ++ | + | + | + | + | + | + | + |
| CQ9878 | 6 | ++ | ++ | + | + | + | + | + | + | + |
| 28-332 | 6 | ++ | ++ | + | ++ | + | + | ++ | + | ++ |
| CQ9112 | 6 | ++ | ++ | + | ++ | + | + | ++ | + | ++ |
+, EBOV RNA- and antigen-positive cells were rarely detected; ++, EBOV-positive cells were occasionally detected; +++, EBOV-positive cells were frequently detected; and −, no EBOV-positive cells were detected. Note: the whole field from each of two sections of each tissue was examined in its entirety.
P.I., postinfection; HEV, high endothelial venules of lymphoid tissues; Sin, hepatic and adrenal cortical sinusoids; Spl, endothelial cells in spleen; Lam prop, lamina propria of tongue, nares, lip, larynx, and intestines; Ren cap, renal capillaries; Alv cap, alveolar capillaries; Heart, endothelial cells in heart; Brach plex, endothelial cells of the brachial plexus; Brain, endothelial cells in capillaries and venules in the brain.