Table 2.
Exploration of Environment and Anxiety of B6Tg2576 Mice
| Tests | Control diet | Atherogenic diet | P |
|---|---|---|---|
| Spontaneous alternation (T-maze) | |||
| Rate (%) | 67.0 ± 6.0 | 60.0 ± 4.0 | 0.39 |
| Latency (s) | 27.8 ± 1.6 | 57.0 ± 14.0 | 0.26 |
| Motor activity (open field) | |||
| Path length (cm) | 2969.6 ± 375.5 | 2182.2 ± 300.3 | 0.15 |
| % time in the central zone | 7.2 ± 1.9 | 5.7 ± 1.7 | 0.59 |
| Anxiety (elevated plus-maze) | |||
| Entries to open arms | |||
| Day 1 | 13.7 ± 2.8 | 8.8 ± 2.7 | 0.24 |
| Day 2 | 9.2 ± 1.7 | 6.0 ± 1.1 | 0.17 |
| % time in open arms | |||
| Day 1 | 68.2 ± 11.3 | 57.3 ± 15.9 | 0.58 |
| Day 2 | 45.1 ± 10.2 | 43.3 ± 16.8 | 0.93 |
B6Tg2576 mice at age of 15–18 months after being fed an atherogenic (n = 5) or a normal control diet (n = 6) for 4 months were tested. The results indicate that the mice fed the atherogenic diet do not differ significantly in exploration of environment, motor activity, and anxiety from mice fed the control diet.