Table 3.

NO Generation by Macrophages Isolated from Control and Nephritic Rats after First Injection of OX7

NO generation in umol/ml	Spontaneous	IFN-γ + TNF (20 U + 10 ng/ml)	IL-4 (8 ng/ml)	TGF-β1 (10 ng/ml)
Control	4.65 ± 0.7	17.73 ± 1.9*	3.93 ± 0.9	3.28 ± 1
1 hour	11.93 ± 1.4	18.65 ± 2.9†	6.43 ± 2.2†	5.7 ± 1.5†
4 hours	15.1 ± 2.5	27.6 ± 3.1†	6 ± 1.3†	7.35 ± 0.8†
7 days	3.48 ± 1.7	23.25 ± 1.1†	3.97 ± 1.8	3.65 ± 2.4

N = 6 for control rats and N = 4 for nephritic rats; mean ± SD.

*P < 0.05 compared with untreated controls.

^†P < 0.05 compared with macrophages from untreated nephritic rats.