Muscle biopsy sections stained with trichrome (a) and hematoxylin and eosin routine stains (b to d). In the “active stage dystrophic process” (a and b) increased fiber size variability, fibro-fatty replacement, and degenerating and regenerating fibers are observed. “Moderate dystrophic process” (c) is characterized by increased fiber size variability, central nuclei, regenerating, and ring fibers. “Mild myopathic process” (d) shows slight fiber size variability and central nuclei. Magnification, ×400.