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. 2003 Nov;163(5):1997–2008. doi: 10.1016/s0002-9440(10)63558-4

Figure 4.

Figure 4.

THC protects the NMDA-induced retinal neurotoxicity by inhibiting ONOO− formation. Rats were given an intravenous injection of THC suspension immediately before the intravitreal injection of NMDA. Effect of systemic THC on the NMDA-induced formation of nitrotyrosine, lipid peroxidation, and nitrite/nitrate in the retina is shown at 18 hours after NMDA injection. All values represent the mean ± SE of four to five animals for each group. *, Significant at P < 0.05. A: Dose-dependent effect of THC on the NMDA-induced relative optical density of nitrotyrosine in retinal cryosections (8 μm) determined by immunohistochemistry. OCT-frozen eye sections perpendicular to the retinal surface were analyzed as described before. B: Effect of THC on the NMDA-induced nitrotyrosine formation determined by immunochemical slot-blot analysis. C: Effect of THC on the NMDA-induced MDA formation in the retina. D: Effect of THC on the NMDA-induced nitrite/nitrate accumulation in the retina.