Table 2.
Blockade of IL-12 Decreases LPS-Induced Leukocyte Infiltration
| Group | n | Total serum IgE (μg/ml) | Peribronchial eosinophils (cells/20 HPF) | Bronchoalveolar lavage | |||
|---|---|---|---|---|---|---|---|
| Total leukocytes (cells/HPF) | PMN (%) | Eosinophils (%) | Lymphs (%) | ||||
| No LPS + NRS | 7 | 4.1 ± 0.7* | 125 ± 44 | 17 ± 1 | 48.3 ± 6.1 | 5.9 ± 2.6 | 1.7 ± 0.4 |
| 15 μg LPS + NRS | 7 | 3.8 ± 0.4 | 40 ± 12 | 70 ± 4† | 86.8 ± 5.6† | 0.4 ± 0.2 | 1.0 ± 0.3 |
| 15 μg LPS + aIL-12 | 9 | 5.5 ± 0.9 | 70 ± 13 | 46 ± 3†‡ | 79.6 ± 4.6† | 1.0 ± 0.2 | 1.2 ± 0.4 |
*Data are combined mean ± standard error from two separate experiments.
†Statistically significant difference (P < 0.05) compared to no LPS control.
‡Statistically significant difference compared to LPS + NRS group.