Table 2.
Some Published Studies of Human Neoplasms Utilizing Phosphorylation State-Specific Antibodies
| Phosphoprotein | Neoplasms | References |
|---|---|---|
| Transmembrane receptor tyrosine kinases | ||
| ErbB-2 | Breast carcinoma | 28-32 |
| EGFR | Non-small cell lung carcinoma (NSCLC), pancreatic carcinoma, testicular erm cell tumors | 33-35, 62 |
| IGF-1R | Breast carcinoma, medulloblastoma | 36-38 |
| CSF-1R | Breast carcinoma | 39 |
| Intracellular kinases | ||
| ERK/MAP kinase | Gliomas, carcinomas (prostate, breast, pancreatic, head/neck) | 19, 40-42, 62 |
| AKT | Carcinomas (epithelial ovarian, endometrial, breast, papillary thyroid, pancreatic, NSCLC), multiple myeloma | 43-48, 62 |
| Transcription factors/nuclear proteins | ||
| STAT3/6 | Hodgkin lymphoma, multiple myeloma, prostate carcinoma | 49-52 |
| Beta-catenin | Colorectal carcinoma | 53 |
| Smad2/4 | Breast carcinoma | 54 |
| I-kappaB alpha | Gynecologic squamous intraepithelial neoplasia/carcinoma | 55 |
| P53 | Transitional cell carcinoma | 56 |
| Rb | Uveal melanoma, retinoblastoma | 57, 58 |
| Histone H1 | Gynecologic squamous intraepithelial neoplasia/carcinoma | 59 |
| c-jun | Breast carcinoma, astrocytoma | 60,61 |