Figure 3.

Cerebral pathology in acute Nipah infection. A: Small vessel vasculitis (arrow) characterized by mild inflammation in the vicinity of infected neurons. B: Focal areas of parenchymal ischemia, infarction, and edema. C: Neurons with eosinophilic viral inclusions (arrows). D: Immunolocalization of viral antigens to neurons in the nucleus (inset, arrow), cytoplasm, and processes near a vasculitic vessel (arrow). E: Viral antigens localized to ependymal lining (arrow) and neurons. F: Neurons demonstrating viral RNA in the cytoplasm (arrows). A–C: Hemalin-phloxine-safranin stain; D, E: IHC, hematoxylin counterstain; F:in situ hybridization, hematoxylin counterstain. Original magnifications: ×40 (A, B, E, D (inset), ×20 (D); ×100 (C, F).