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. 2003 Nov;163(5):1801–1815. doi: 10.1016/S0002-9440(10)63540-7

Figure 3.

Figure 3.

Confocal microscopic images of type IV collagen immunoreactivity of basement membrane (A, C) and CD31 immunoreactivity of endothelial cells (B, D) in normal pancreatic islet of wild-type mouse (A, B) and in RIP-Tag2 tumor (C, D). In both cases, all CD31-immunoreactive vessels co-localize with type IV collagen immunoreactivity. Tumor vessels are more irregular and tortuous but still have a uniform envelopment of type IV collagen immunoreactivity. Arrowheads mark tumor vessels where type IV collagen staining (C) is broader or more prominent than the corresponding CD31 immunoreactivity (D), suggestive of a loose association with endothelial cells. Arrows in A point to exocrine pancreatic acini outlined by type IV collagen immunoreactivity. Scale bar, 50 μm (A–D).