Table 1.
Preterm Parturition and Fetal Viability Based on Mouse Strain and Treatment
| Mouse strain | Treatment(s) | n | Preterm delivery rate (%) | Mean number of live pups per undelivered dam at 48 hours | Mean number of IUFDS per undelivered dam at 48 hours |
|---|---|---|---|---|---|
| CD-1 | Saline | 8 | 0/8 (0) | 11.5 ± 1.9 | 0.2 ± 0.4 |
| CD-1 | LPS (L2880) 250 μg/mouse | 16 | 16/16 (100) | 0 | NA* |
| CD-1 | PAF (10–40 μg/mouse) | 9 | 4/9 (44) | 7.0 ± 1.4 | 5.5 ± 3.5 |
| CD-1 | LPS (L2880) 250 μg/mouse + PAF antagonists 3–6 mg/kg) | 24 | 10/24 (58) | 6.7 ± 3.2 | 4.9 ± 2.8 |
| C3H/HEJ | LPS (L2880) 250 μg/mouse | 10 | 4/10 (40) | 3.0 ± 3.7 | 2.2 ± 1.0 |
| C3H/HEJ | LPS (L4524) 250 μg/mouse | 3 | 0/3 (0) | 6.3 ± 1.5 | 1.7 ± 1.2 |
*Since all animals receiving LPS alone delivered preterm, there were no remaining live or dead pups in the uterine horns at 48 hours.