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. 2003 Nov;163(5):2113–2126. doi: 10.1016/S0002-9440(10)63568-7

Figure 8.

Figure 8.

Lost expression of integrin-β1 in PyMT-induced lesions. A to C: IHC of integrin-β1 in mammary gland of a PyMT mouse at 4 weeks of age. A: Staining of primary lesion. Note that the positive staining is in the baseline of a morphologically normal duct (arrows) but no such staining is in the adjacent hyperplastic lesion (open arrows). The inset in A is shown in B. Arrows point to the positively stained areas and open arrows point to negatively stained adjacent hyperplastic lesions. C: The staining of a morphologically normal duct in the same mammary gland shown in A. Arrows point to positively stained areas. D and E: Staining for integrin-β1 of a PyMT-induced mammary tumor at late carcinoma stage. D: The primary tumor. Arrows point to the center of the tumor with negative staining of integrin-β1. E: Staining of secondary lesions in the same mammary gland. Arrows point to the positive stained area. Scale bars: 25 μm (A, C); 10 μm (B, D, E). Original magnifications: ×400 (A, C); ×1000 (B, D, E).