Table 1.

Neuritic Dystrophy in the Prevertebral Sympathetic Ganglia of NOD and NOD-SCID Mice

Mouse	n	Blood glucose (mg%)	SMG-CG dystrophy (no. dystrophic neurites/no. neuron)
Diabetic NOD	9	≥600	1.25 ± 0.35*
Controls (non-DM sibs)	5	104 ± 14	0.06 ± 0.01
NOD-SCID	6	106 ± 8	0.22 ± 0.03†

Dystrophic neurites (expressed as number per nucleated neuron) in the SMG-CG of female NOD mice diabetic for 3–5 weeks show a dramatic increase in frequency in comparison to non-diabetic siblings. Dystrophic neurites in SMG-CG of 25-week-old female NOD-SCID mice (ie, age-matched to diabetic NOD mice) show a marked decrease in frequency compared to diabetic NOD mice. Values represent the means ± SEM. Statistical comparison:

*p ≤ 0.01 vs. control;

^†p<0.01 vs. diabetic NOD.