Table 3.
Effect of Streptozotocin-Induced Diabetes on Neuritic Dystrophy as a Function of Mouse Strain, Sex, and Duration of Diabetes
| Strain | Mice (n) | Sex | Duration of diabetes | Blood glucose (mg%) | SMG-CG dystrophy (no. dystrophic neurites/no. neuron) |
|---|---|---|---|---|---|
| B6D2F1 | |||||
| Control | 8 | M | 5 months | 122 ± 18 | 0.01 ± 0.003 |
| Diabetic | 7 | 480 ± 48 | 0.30 ± 0.07* | ||
| Control | 3 | M | 12 months | 147 ± 8 | 0.08 ± 0.02 |
| Diabetic | 1 | 558 | 0.83 | ||
| C57BL6 | |||||
| Control | 5 | M | 2–3 months | 129 ± 13 | 0.039 ± 0.017 |
| Diabetic | 5 | 426 ± 23 | 0.112 ± 0.017† | ||
| Control | 4 | M | 5 months | 224 ± 10 | 0.02 ± 0.01 |
| Diabetic | 3 | 397 ± 85 | 0.18 ± 0.03† | ||
| DBA/2J | |||||
| Control | 5 | M | 2–3 months | 136 ± 6 | 0.006 ± 0.004 |
| Diabetic | 8 | 525 ± 34 | 0.128 ± 0.03* | ||
| BL6/NCR | |||||
| Control | 3 | F | 3 weeks | 142 ± 12 | 0.003 ± 0.003 |
| Diabetic | 7 | 508 ± 29 | 0.036 ± 0.005‡ |
Values represent the means ± SEM of n mice. Statistical comparison.
*p, ≤ 0.01; †p, ≤ 0.05, ‡ p, ≤ 0.001 vs. matched control group.