Table 2.
Titration of Antibody Concentrations to Induce CAIA in BALB/c and QB Mice
| Mouse strain | Antibodies (mg) | Incidence | Max score (mean ± SEM) | ||
|---|---|---|---|---|---|
| A | L | A | L | ||
| BALB/c | 3 | 2/6 | 4/6 | 1.3 ± 0.8 | 11.5 ± 6.4 |
| 6 | 2/4 | 3/4 | 3.0 ± 2.3 | 21.3 ± 7.6 | |
| 9 | 7/7 | 7/7 | 5.7 ± 1.3 | 31.4 ± 3.2 | |
| 18 | 5/5 | 5/5 | 5.0 ± 0 | 30.2 ± 4.3 | |
| 3 | 0/3 | 1/3 | 0 | 1.6 ± 1.6 | |
| QB | 6 | 1/3 | 1/3 | 1.6 ± 1.6 | 5.0 ± 5.0 |
| 9 | 7/12 | 11/12 | 3.3 ± 1.5 | 19.1 ± 4.0 | |
Groups of 4 to 6 months-old naïve BALB/c and QB mice were injected with different amounts of the cocktail of monoclonal antibodies on day 0. All the mice received LPS i.p. on day 5. A, arthritis susceptibility at day 5 (before LPS injection). L, maximal arthritis after LPS injection.