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Tumor spectrum is changed in tTA/TAg/ER-α transgenic mice. Mammary adenocarcinomas developed only in triple-transgenic tTA/TAg/ER-α mice (females, n = 10; males, n = 1). Significantly fewer triple-transgenic females develop lymphomas than double-transgenic females (*, P = 0.014; chi-square test). M & S, development of both mammary and salivary adenocarcinomas.
