Table 1.

Metabolic Parameters of Wild-Type and KLF15^−/− Mice

	Fed		Fasted
	WT	KLF15−/−	WT	KLF15−/−	n
Hepatic glycogen content (mg/g liver)	41.09 ± 3.24	40.87 ± 3.17	1.98 ± 0.60	0.57 ± 0.17*	7
FFA (mEq/l)	0.52 ± 0.04	0.97 ± 0.04*	1.11 ± 0.06	1.15 ± 0.05	15–18
β-hydroxybutyrate (mmol/l)	0.28 ± 0.02	0.30 ± 0.03	1.26 ± 0.15	3.04 ± 0.28*	5–10
Glycerol (mg/dl)	0.79 ± 0.05	1.34 ± 0.08*	0.83 ± 0.05	1.68 ± 0.08*	17–20
Lactate (mmol/l)	3.96 ± 0.15	3.05 ± 0.18*	2.18 ± 0.09	1.76 ± 0.07*	17–19
Insulin (ng/ml)	2.78 ± 0.31	2.45 ± 0.28	0.08 ± 0.02	0.06 ± 0.01	12–17
Glucagon (pg/ml)	51.78 ± 2.00	79.47 ± 6.67*	38.05 ± 1.29	54.00 ± 2.84*	10–18

Mice were 3–4 months old for all measurements. Assays of blood samples were performed on isolated serum, except β-hydroxybutyrate values, which were determined on whole blood. Values are means ± SEM.

^*Significantly different compared to WT control (Student’s t test for unpaired samples; p < 0.05). FFA, free fatty acids; Fed, animals bled or sacrificed between 9:00 and 10:00 a.m.; Fasted, animals fasted overnight (18 hr).