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. Author manuscript; available in PMC: 2007 Jun 15.
Published in final edited form as: Nature. 2003 Jul 23;424(6949):685–689. doi: 10.1038/nature01887.

Figure 5.

Figure 5

PAR-1 inhibits, and MEX-5 and MEX-6 activate, ZIF-1-dependent degradation. a, 12/15-cell embryos expressing GFP::PIE-1ZF1 with genes inactivated by RNAi. GFP::PIE-1ZF1 is degraded in somatic blastomeres in wild type, and in all cells in par-1(RNAi) embryos. Ubiquitous degradation in par-1(RNAi) requires ZIF-1, MEX-5, MEX-6 and CUL-2. Similar results were obtained with PIE-1::GFP (Supplementary Information). b, Schematic summarizing the epistatic relationships deduced from a and ref. 6.