. Author manuscript; available in PMC: 2008 Mar 15.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2006 Dec 29;67(4):1074–1081. doi: 10.1016/j.ijrobp.2006.10.023

Table 4.

Multivariate Analysis of Potential Predictors of Biochemical Failure and Distant Metastasis

	Biochemical Failure						Distant Metastasis
	ASTRO^*			Nadir+2^†
Predictor	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
T-stage
T3-4 (vs T1-2)	1.94	1.34 to 2.82	.0005	1.76	1.19 to 2.60	.004	2.49	1.20 to 5.16	.014
Gleason score
7-10 (vs 2-6)	1.48	1.13 to 1.95	.005	1.80	1.34 to 2.41	<.0001	3.56	1.90 to 6.67	<.0001
iPSA (continuous)
1 ng/mL increase	1.02	1.01 to 1.02	<.0001	1.02	1.01 to 1.02	<.0001	1.02	1.01 to 1.03	.0001
RT Dose (continuous)
1 Gy increase	0.92	0.88 to 0.95	<.0001	0.93	0.90 to 0.97	.001	0.88	0.80 to 0.96	.006

Abbreviations: ASTRO = American Society of Therapeutic Radiation Oncology; iPSA = initial pretreatment prostate-specific antigen level; RT = radiotherapy; Gy = Gray; HR = hazard rate; CI = confidence interval.

ASTRO definition of biochemical failure: 3 consecutive rises in PSA, with BF backdated to midpoint between nadir and the first rise (16).

^†

Nadir+2 definition of biochemical failure: PSA ≥ nadir + 2ng/mL (18-22).