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. 2007 Jun 8;3(6):e109. doi: 10.1371/journal.pcbi.0030109

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© 2007 Thakar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Time course patterns of key nodes (y-axis) plotted against time steps (x-axis) during secondary infection by B. bronchiseptica (Bb) and B. pertussis (Bp). One time step corresponds to 1 d to 2 d. The initial state corresponds to the activity of immune system components at the start of the secondary infection. Two scenarios are shown: secondary infection given in phase II of the primary infection (third column), or in phase III of the primary infection (fourth column).