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. Author manuscript; available in PMC: 2008 Mar 26.
Published in final edited form as: Neurosci Lett. 2007 Jan 5;415(2):118–123. doi: 10.1016/j.neulet.2007.01.004

Figure 1. Allopregnanolone significantly reduces GABAergic transmission in Ce.

Figure 1

a). Traces of the evoked inhibitory postsynaptic current (eIPSC) recorded from a Ce neuron under voltage-clamp mode and in the presence of DNQX (20 μM) and D-APV (50 μM). eIPSCs at different holding potentials show a reversal potential between −60 to −70 mV. b). The eIPSC is PTX sensitive, and when held at 0 mV without glutamate receptors blockers, has virtually no contamination from other sources (such as the EPSC). c). Traces from another Ce neuron show a reduction of the eIPSC after allopregnanolone (100 nM). This effect could not be washed off after 30 min of washing. Each trace was an average of 10 consecutive responses under the same condition. d). Bar graph of the averaged results shows a significant inhibition of 31.0 ± 4.0% by ALLO. ** p < 0.01 (paired t-test).