Table 3.

Organ distribution (% dose/organ, n = 3) and regional brain uptake (% dose/g) of [¹²⁵I]8 in rats (iv injection)

Organ	2 min	30 min	60 min	120 min	240 min
Blood	11.22 ± 0.26	5.19 ± 0.63	4.48 ± 0.07	4.11 ± 0.24	3.76 ± 0.20
Heart	0.57 ± 0.05	0.14 ± 0.03	0.09 ± 0.01	0.10 ± 0.01	0.06 ± 0.01
Muscle	15.37 ± 1.42	9.23 ± 1.27	6.64 ± 0.14	6.03 ± 0.60	4.95 ± 0.67
Lung	3.90 ± 0.44	1.41 ± 0.20	0.63 ± 0.00	0.36 ± 0.07	0.22 ± 0.01
Kidney	2.79 ± 0.11	1.66 ± 0.23	1.32 ± 0.14	0.74 ± 0.10	0.45 ± 0.05
Spleen	0.64 ± 0.19	0.37 ± 0.11	0.19 ± 0.00	0.13 ± 0.03	0.08 ± 0.00
Liver	21.2 ± 1.80	5.70 ± 0.65	5.32 ± 1.10	4.81 ± 0.47	3.81 ± 0.30
Skin	8.44 ± 0.91	13.2 ± 0.17	11.76 ± 0.48	11.0 ± 1.54	11.5 ± 4.49
Brain	0.92 ± 0.12	0.74 ± 0.16	0.55 ± 0.01	0.29 ± 0.07	0.08 ± 0.01
Thyroid	0.07 ± 0.00	0.16 ± 0.04	0.44 ± 0.07	1.24 ± 0.47	3.75 ± 1.00
Regional brain distribution (% dose/g)
Region	2 min	30 min	60 min	120 min	240 min
Cerebellum	0.48 ± 0.06	0.22 ± 0.06	0.11 ± 0.01	0.04 ± 0.01	0.02 ± 0.00
Striatum	0.46 ± 0.05	0.43 ± 0.09	0.35 ± 0.01	0.19 ± 0.03	0.05 ± 0.00
Hippocampus	0.41 ± 0.06	0.38 ± 0.08	0.30 ± 0.02	0.16 ± 0.04	0.05 ± 0.00
Cortex	0.59 ± 0.08	0.45 ± 0.09	0.30 ± 0.02	0.13 ± 0.03	0.03 ± 0.00
Hypothalamus	0.46 ± 0.05	0.50 ± 0.09	0.43 ± 0.04	0.24 ± 0.05	0.08 ± 0.01
Ratio to Cerebellum
Region	2 min	30 min	60 min	120 min	240 min
Cerebellum	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
Striatum	0.95 ± 0.03	2.01 ± 0.11	3.28 ± 0.31	4.39 ± 0.16	3.09 ± 0.01
Hippocampus	0.86 ± 0.03	1.76 ± 0.07	2.77 ± 0.23	3.57 ± 0.16	2.80 ± 0.13
Cortex	1.24 ± 0.02	2.11 ± 0.11	2.76 ± 0.05	2.87 ± 0.07	2.00 ± 0.11
Hypothalamus	0.97 ± 0.01	2.32 ± 0.17	3.97 ± 0.08	5.57 ± 0.12	5.06 ± 0.60