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. 1992 Jan;36(1):227–229. doi: 10.1128/aac.36.1.227

Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.

K Suomalainen 1, T Sorsa 1, L M Golub 1, N Ramamurthy 1, H M Lee 1, V J Uitto 1, H Saari 1, Y T Konttinen 1
PMCID: PMC189275  PMID: 1317148

Abstract

The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.

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Selected References

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