Table 1.

Effect of reparixin on cortical vs. subcortical damage 24 h after transient MCAO

	Total infarct	Cortex	Striatum
Experiment 1
Saline (n = 6)	273 ± 24	181 ± 24	89 ± 9
Reparixin (n = 5)	68 ± 8 **	12 ± 4 **	56 ± 9 *
Experiment 2
Saline (n = 8)	271 ± 25	193 ± 19	78 ± 8
Reparixin (n = 7)	143 ± 23 *	64 ± 18 **	79 ± 8

Results from 2 independent experiments are given. Data are expressed as the infarct volume in mm³ and are the mean ± S.E; the number of rats per group is indicated in parenthesis. Experiment 1: reparixin was administered on the first day at 15 mg/kg i.v. starting 2 h after reperfusion followed by two 15 mg/kg s.c. doses at 2 h intervals. Experiment 2: reparixin was administered on the first day at 15 mg/kg i.v. starting at the time of ischemia followed by four 15 mg/kg s.c. doses at 2 h intervals. Infarct volumes are determined 24 h after MCAO.

^*P < 0.05 and

^**P < 0.01 vs. saline (Student t-test).