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Bioassays of prions in ScN2a cells treated with 22-mer PS-DNA
| Host | Inoculum | Length of experiment (days) | Mean incubation period ± SEM (days) | n/n0a |
|---|---|---|---|---|
| CD-1 | ScN2a cells | — | 148 ± 2 | 10/10 |
| CD-1 | ScN2a cells treated with PS-DNA for 8 weeks | > 600 | 305 ± 50 | 5/6 |
| Tg(MoPrP-A)4053 | ScN2a cells | — | 68 ± 2 | 10/10 |
| Tg(MoPrP-A)4053 | ScN2a cells treated with PS-DNA for 8 weeks | > 400 | - | 0/6 |
n, number of mice with neurologic symptoms; n0, number of inoculated mice.
