Table 2.
Postmortem levels of NA, DA, and 5-HT in selected brain regions of control (n=5) and anti-DBH–saporin lesioned rats (n=5)
| NA |
DA |
5HT |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (pmol/mg) | SAP lesion (pmol/mg) | Depletion (%) | Control (pmol/mg) | SAP lesion (pmol/mg) | Depletion (%) | Control (pmol/mg) | SAP lesion (pmol/mg) | Depletion (%) | |
| IL | 2.99(0.60) | 0.31(0.14) | 89.7** | 1.48(0.35) | 0.64(0.13) | 56.6 | 0.92(0.19) | 0.91(0.25) | 0.6 |
| PRL | 1.86(0.27) | 0.40(0.31) | 78.5** | 0.50(0.12) | 0.82(0.15) | 0.0 | 1.11(0.32) | 1.06(0.20) | 5.0 |
| CG1 | 1.56(0.17) | 0.31(0.18) | 80.3** | 0.30(0.09) | 0.37(0.07) | 0.0 | 0.94(0.21) | 0.75(0.12) | 19.5 |
| OFC | 1.65(0.31) | 0.41(0.24) | 75.2* | 0.83(0.28) | 0.46(0.10) | 45.0 | 0.90(0.08) | 1.04(0.09) | 0.0 |
| PostPAR | 1.64(0.27) | 0.54(0.28) | 67.4* | 0.93(0.41) | 0.58(0.27) | 37.3 | 0.53(0.14) | 0.56(0.11) | 0.0 |
| THAL | 2.92(0.94) | 0.94(0.21) | 67.7 | 0.42(0.11) | 0.24(0.04) | 41.5 | 0.97(0.47) | 0.47(0.16) | 51.4 |
| HYPO | 7.13(1.93) | 9.04(1.43) | 0.0 | 0.47(0.08) | 0.65(0.12) | 0.0 | 1.41(0.52) | 1.92(0.45) | 0.0 |
| dHIPP | 2.77(0.53) | 1.29(0.31) | 53.3* | 0.27(0.04) | 0.20(0.03) | 24.7 | 0.57(0.23) | 0.62(0.15) | 0.0 |
| vHIPP | 3.96(0.49) | 2.30(0.56) | 41.9 | 0.30(0.03) | 0.03(0.02) | 0.0 | 1.61(0.60) | 1.69(0.23) | 0.0 |
The data are averaged levels (±SEM) expressed as picomoles per milligram.
IL Infralimbic cortex, PRL prelimbic cortex, CG1 anterior cingulate cortex, OFC orbitofrontal cortex, PostPAR posterior parietal cortex, THAL thalamus, HYPO hypothalamus, dHIPP dorsal hippocampus, vHIPP ventral hippocampus
p<0.05 (control vs lesion, independent t test)
**
p<0.01 (control vs lesion, independent t test)