Table 1.
Experimental evidence for predicted ESE hexamers.
| 9mer ESE | ESE Score | Mutant ESE | Mutant Score | Contained Hexamer Motifs |
| GAAGAAGAA | 5 | GCAGAAAAA | -1 | gaagaa, aagaag |
| TGCTGCTGG | 5 | tgctgc, gctgct | ||
| TGCAGCTGG | 5 | gcagct, cagctg | ||
| GAAGATGGA | 5 | gaagat, aagatg, gatgga | ||
| GAAGGAAGA | 5 | gaagga, aaggaa, ggaaga | ||
| GAGAAGAAG | 5 | gagaag, gaagaa, aagaag | ||
| TTGGAGCAA | 5 | ttggag, ggagca | ||
| AGCTGCTGG | 4 | agctgc, gctgct | ||
| TGCTGGTGG | 4 | tggtgg | ||
| TGCTGCAGG | 4 | tgctgc, ctgcag | ||
| TGCTGCTCG | 4 | tgctgc, gctgct | ||
| TGCTGCTGC | 4 | TACTTCTGC | -3 | tgctgc, gctgct |
| GAGGATTGA | 4 | GAGAATTGA | -1 | gaggat |
| TGCAGATGA | 4 | gcagat, cagatg | ||
| CAAGAAACA | 4 | aagaaa | ||
| GAAGAGAAA | 4 | GCAGAAAAA | -1 | aagaga |
| AAAGGAGAT | 4 | aaggag, aggaga, ggagat | ||
| GAAGAAAGA | 4 | gaagaa, aagaaa | ||
| GAGCAGAAG | 4 | gagcag | ||
| TGCTGCCGC | 4 | tgctgc | ||
| TTGAAGAAG | 3 | TTGAAAAAG | -3 | ttgaag, tgaaga, gaagaa, aagaag |
| TTGAAGCTG | 3 | TTAAAGCTG | -3 | ttgaag, tgaagc, gaagct, aagctg |
| GAAGATTGA | 3 | GAGAATTGA | -1 | gaagat |
| TTTGGTGGA | 3 | tggtgg, ggtgga | ||
| ATGGAGAAA | 3 | ATTGAGAAA | -3 | atggag, tggaga, ggagaa |
Hexamer motifs that are contained within experimentally confirmed 9-mers with ESE activity (column 5). Experiments to confirm 9-mers are described elsewhere (S. Mount et al., manuscript in preparation). Column 1 shows the containing ESE ninemer, and column 3 shows ninemers without ESE activity, which are situated within 1–2 bp edit distance from the ESE ninemer. The ESE activity of each 9-mer in the table is shown by a score equal to log2(inclusion/skipping) [34].