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. 2007 Jun 12;5(6):e153. doi: 10.1371/journal.pbio.0050153

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© 2007 Bertin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Consistency of the party/date attribution between FYI and filtered-HC. Because filtered-HC network has many more interactions than FYI, only 162 of the 546 hubs in filtered-HC had been previously found in FYI. Filtered-HC confirmed 86% of the party/date designations in FYI. In addition, 20% of FYI hubs are not considered as hubs anymore in the new filtered-HC network because of the higher connectivity threshold.

(B) The effect on the characteristic path length (top panels) and main component size (bottom panels) of the networks upon gradual node removal for HC (left panels) and filtered-HC (right panels). Attacks against all hubs (brown curve), party hubs (blue curve), date hubs (red curve), and random nodes (green curve). Insets show an additional control for connectivity differences between categories with the x-axis representing the number of edges removed from the network.

(C) Date hubs participate in more genetic interactions than party hubs or non-hubs [2], as measured here by mean number of interactions [1] from a network of curated genetic interactions [32] for both filtered-HC (right panel) and HC (left panel). Inside each panel, bars show the number of genetic interactions held by date hubs (red), party hubs (blue), and non-hub proteins (yellow). The p-values assessing the difference of the means between date and party hubs (Mann-Whitney U-test) are indicated above the bars.