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Epo expression after stress-induced erythropoiesis depends on HIF-2α. (A) Spleen-to-body weight ration of PH untreated and treated Hif-2αfl/Δ and Hif-2αΔ/Δ mice. (B) Serum EPO levels from PH treated Hif-2α fl/fl, fl/Δ, and Δ/Δ mice. (C) Hif-1α fl/fl and Δ/Δ mice do not exhibit any defects in EPO stimulation after PH treatment. (D) Hematocrit values increase in Hif-2αfl/Δ and Hif-2αΔ/Δ animals because of EPO treatment and reach normal levels after 2 weeks in Hif-2αΔ/Δ mice.
