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Cytotoxic effect of MCP-1 on RD-induced photoreceptor apoptosis. (A and B) TUNEL 72 h after RD in WT mice (A) and MCP-1−/− mice (B). (Scale bar: 50 μm.) (C and D) TEM photomicrographs through the ONL 72 h after RD in WT mice (C) and MCP-1−/− mice (D). Note the increased presence of apoptotic photoreceptors in WT mice compared with MCP-1−/− mice (arrows). (Scale bar: 10 μm.) (E) Quantification of TUNEL+ cells (n = 8 each). ∗, P < 0.05.
