Fig. 3.

RU increase in Lnk−/− CD34⁻KSL cells after culture. Forty WT (Left) or Lnk−/− (Right) CD34⁻KSL cells were transplanted (n = 8). Similar cells alternatively were cultured with SCF (50 ng/ml) and/or TPO (50 ng/ml) for 3 days, and then transplanted (n = 8). RUs before (n = 8) and after culture were compared 12 weeks after transplantation. Data are shown in terms of fold increase (average RU before culture = 1.0). RUs significantly increased in Lnk−/− CD34⁻KSL cells after culture with TPO (P = 0.025) or SCF plus TPO (P = 0.046). ∗, P < 0.05 vs. before culture.