TABLE 1.
Genetic modifiers of Ppt1-induced degeneration
| Gene | Mammalian homolog | Line | Insertion | Modificationa | Verificationb | Loss-of-function allelesc |
|---|---|---|---|---|---|---|
| Endocytosis/trafficking | ||||||
| Endophilin A | Endophilin A | EP(3)464 | 91D4 | Enh | UAS | endoAΔ4/NE |
| CG14709 | Multidrug resistance-associated protein | EP(3)430 | 86E11 | Enh | In situ | NA |
| Blue cheese | ALFY | EY(3)2503 | 26A6 | Enh | In situ | NA |
| CG5991 | Phosphatidylserine decarboxylase | EY(3)3559 | 95D5 | Enh | In situ | NA |
| CG32138 | Formin-like 2 | EY(3)3931 | 70D1 | Enh | In situ | NA |
| Ubiquitination | ||||||
| Fat facets | Ubiquitin protease 9 | EY(3)2018 | 100E1 | Enh | UAS | fafBX4/NE |
| UbcE2H | Ubc-E2H | EP(X)1303 | 7D6 | Sup | In situ | NA |
| CG7023 | Ubiquitin protease 12-like | EY(3)249 | 94C4-6 | Sup | In situ | NA |
| Cell adhesion | ||||||
| Myospheroid | β-integrin | EP(X)1033 | 7D3-5 | Enh | UAS | mys1/NE |
| Fasciclin 2 | NCAM2 | EP(X)1462 | 4B1-3 | Sup | UAS | fasIIeb112/NE |
| Miniature | Novel | EP(X)406 | 10D8 | Sup | In situ | m1/NE |
| Signaling pathways | ||||||
| Misshapen | Ste20-related kinase | EP(3)549 | 62E6-7 | Enh | UAS | msn102/NE |
| Kayak | FosB | EY(3)283 | 99C2 | Sup | UAS | kaysro-1/NE |
| Saxophone | TGF-β receptor type I | EY(2)4377 | 43E18 | Sup | UAS | sax5/NE |
| Mesr4 | Novel | EP(2)386 | 54C3-7 | Sup | In situ | NA |
| Fs(1)N | Novel | EP(X)1336 | 1F01-02 | Sup | In situ | fs(1)N1/E |
| Miscellaneous | ||||||
| Hsc70-3 | BiP chaperone | EP(X)1507 | 10E3-4 | Sup | In situ | NA |
| CG18177 | N-acetyltransferase | EP(3)3301 | 67C5 | Enh | In situ | NA |
| CG3654 | Novel | EY(3)142 | 67B9 | Enh | In situ | NA |
| CG5859 | Integrator complex subunit 8 | EP(2)2090 | 53D13 | Sup | In situ | NA |
a
Enh, enhancer; Sup, suppressor.
b
UAS, published line; In situ, In situ hybridization.
c
Loss-of-function alleles used for each gene; NE, no effect; E, enhance; NA, no specific alleles available.