Figure 3.—

Effects of time difference between two mutational events on the fixation probability of the coadapted haplotype A₁B₁ in a subdivided population. Simulation results are illustrated for T = 1, 100, and 10,000. Other parameters are N = 1000, L = 10 (N_T = 10,000), s = 0.01, and c = 0.5. Note that when T = 1 and 100, the results practically overlap with each other, whereas for T = 10,000, the effect of migration is less significant. Theoretical expectations derived from the diffusion and birth-and-death models are also illustrated; the scaled probabilities are 1.000 (dotted line, diffusion approximation) and 1.191 (dashed line, birth-and-death approximation), respectively.