Figure 7.—

A summary of synthetic genetic interactions between Abp1p SH3 domain targets and genes that are required in the absence of the Abp1p SH3 domain, which function in endocytic internalization. The “coat module” consists of a complex of endocytic coat proteins that are recruited early to endocytic sites at the plasma membrane. The “actin module” provides the actin polymerization that drives endocytic coat internalization and facilitates disassembly. Phosphorylation of coat proteins Sla1p and Pan1p by the Abp1p SH3 domain targets, Ark1p and Prk1p kinases, mediates endocytic coat protein complex disassembly.