TABLE 8.
Empirical power to detect a tumor initiator for varying scenarios regarding the penetrances of homozygotes and heterozygotes
| Family size
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Penetrance
|
70
|
200
|
500
|
2000
|
|||||
| ΨTT | ΨTt | α = 0.01 | α = 0.05 | α = 0.01 | α = 0.05 | α = 0.01 | α = 0.05 | α = 0.01 | α = 0.05 |
| 0.10 | 0.00 | 10.18 | 28.63 | 37.12 | 76.64 | 91.71 | 98.81 | 100.00 | 100.00 |
| 0.25 | 0.00 | 31.30 | 64.98 | 93.76 | 99.09 | 100.00 | 100.00 | 100.00 | 100.00 |
| 0.50 | 0.00 | 82.75 | 95.73 | 99.98 | 99.99 | 100.00 | 100.00 | 100.00 | 100.00 |
| 1.00 | 0.00 | 99.62 | 99.97 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
| 1.00 | 0.50 | 89.97 | 97.68 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
The values are the percentage of replicates that were higher than thresholds at α = 0.01 and α = 0.05 in a computer simulation of the null hypothesis.