TABLE 3.
Expressing HA-PP1c in a PP1β9C (PP1β9C6) mutant background (from cross w, PP1β9C6/FM7c × w ; arm-Gal4, UAS-HA-PP1c/TM6B)
| F1 genotype | UAS-HA-PP1β9C | UAS-HA-PP1α87B | UAS-HA-PP1α96A |
|---|---|---|---|
| w, PP1β9C6/Y ; arm-Gal4, UAS-HA-PP1c/+ | 47 | 0 | 1 |
| w, PP1β9C6/Y ; TM6B/+ | 0 | 1 | 1 |
| FM7c/Y ; arm-Gal4, UAS-HA-PP1c/+ | 28 | 40 | 35 |
| FM7c/Y ; TM6B/+ | 9 | 17 | 30 |
| w, PP1β9C6/+ ; arm-Gal4, UAS-HA-PP1c/+ | 46 | 37 | 37 |
| w, PP1β9C6/+ ; TM6B/+ | 20 | 33 | 44 |
| FM7c/+ ; arm-Gal4, UAS-HA-PP1c/+ | 48 | 48 | 35 |
| FM7c/+ ; TM6B/+ | 27 | 30 | 35 |
| Total | 225 | 206 | 218 |
PP1β9C6 is a strong, semilethal allele of PP1β9C. Overexpression of HA-PP1β9C rescues the semilethality of PP1β9C6, while overexpression of HA-PP1α does not, showing that PP1β9C is not functionally redundant with PP1α.