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. 2000 Dec 5;97(26):14461–14466. doi: 10.1073/pnas.250491597

Figure 2.

Figure 2

Introduction of the NZB mtDNA into the female mouse germ line and its maternal inheritance. DNA isolated from tail biopsy tissue was PCR-amplified and digested. The highly chimeric female is indicated by the checkered circle on the top line of the pedigree. She was mated to a B6 male to generate the founding female. Heteroplasmic individuals are represented by half-shaded squares (males) or circles (females). B6 mice were used as mates to test the inheritance of the NZB mtDNA. W is the common haplotype (wild type) mtDNA from the 129SvEv ES cell line CC9.3.1. N is the NZB mtDNA.