Figure 5.

Retinal light histology of 6-mo-old CAP^R chimeric mice. (A) Preservation of retinal layers and a gliotic membrane on the inner retina (Magnified ×400.) (B) The pigment epithelial vacuolization and full preservation of outer photoreceptors. (Magnified ×600.) (C) The optic nervehead (ONH) light histology demonstrating hamartomatous-like changes intraocularly, with a gliotic membrane emanating from the ONH surface. (Magnified ×200.) (D) A similar ONH finding but with the presence of an optic pit (*; magnified ×300) in another CAP^R chimeric mouse. GC = ganglion cell layer, IPL = inner plexiform layer, INL = inner nuclear layer, ONL = outer nuclear layer, IS = inner segment, OS = outer segment of photoreceptors, and PE = pigment epithelium.