Figure 3.

Frequency of IL10-+/5′A or 5′A/5′A genotypes in defined categorical analysis. Only seroconverters were included in earlier categories to avoid a survivor's frailty bias (32, 33). A 10-year cutoff in Caucasians and a 7-year cutoff in African Americans were chosen so that seroprevalents from a variety of cohorts would still be included, and failures in seroconverters before that time could be considered. The numbers above bars are the total number of patients in each category. (A) All Caucasians; (B) intravenous drug users (AIDS Link to the Intravenous Experience); (C) combined ethnic groups; (D) Homosexual cohorts (Multicenter AIDS Cohort Study and San Francisco City Clinic Study); and (E) hemophiliac cohorts (Multicenter Hemophiliac Cohort Study and Hemophilia Growth and Development Study). P values are marked as follows: *, <0.05, *, <0.01, and ***, <0.001.