Table 1.
Genotype association analysis for alleles of STR loci adjacent to HIV-1/AIDS candidate genes
| Locus (chromosome) | Infection
|
Progression (AIDS-1993)
|
|---|---|---|
| P value (df) | P value (allele) | |
| IL10 (1q)* | 0.03 (10) | 0.17 (157) |
| IL10 (1q)* | 0.43 (5) | 0.003 (283) |
| IL1A (2q) | 0.65 (10) | 0.14 (327) |
| IL1RA (2q) | 0.39 (10) | 0.15 (93) |
| CCR2/CCR5 (3p)* | 0.07 (3) | 0.05 (214) |
| CCR2/CCR5 (3p)* | 0.06 (4) | 0.0009 (197) |
| STRL33 (3p)* | 0.18 (6) | 0.05 (137) |
| IL5RA (3p) | 0.33 (10) | 0.48 (251) |
| IL2 (4q) | 0.44 (14) | 0.11 (202) |
| GC (4q) | 0.36 (6) | 0.14 (268) |
| IL9 (5q) | 0.97 (11) | 0.21 (425) |
| TBP (6q) | 0.07 (13) | 0.17 (183) |
| TNFB (6p) | 0.28 (1) | 0.19 (162) |
| IFNA (9p) | 0.69 (6) | 0.34 (145) |
| CD4 (12p) | 0.27 (8) | 0.10 (226) |
| IFNG (12q) | 0.82 (8) | 0.19 (189) |
| ERBAL2 (19p) | 0.38 (11) | 0.13 (183) |
| IL2RB (22q) | 0.33 (11) | 0.53 (285) |
| PFC (Xp) | 0.10 (12) | 0.41 (240) |
Analyses of HIV-1-infected (n = 420) seroconverters and antibody-negative individuals (n = 90) were performed for Caucasian Americans (P values of allele frequency differences are shown). AIDS progression tests were performed for 410 Caucasian seroconverters for the AIDS-1993 (14) outcome by Cox analyses (15, 16). Homozygotes and heterozygotes were analyzed separately for alleles with frequencies >0.25 and were combined when the frequencies were >0.03 by stepwise relative hazard regression. STR allele names reflect the molecular size in nucleotide base pairs of the allelic PCR segment. When P values were corrected (17) by the number of tests performed at that locus for AIDS-1993, IL10 was P′ = 0.02, whereas CCR2/5 P′ = 0.20 and P′ = 0.005. A step-down Holm–Sidak correction (17–19) for the 19 loci as a family of tests produced significant association of CCR2/5-linked STRs (P′ = 0.016) and IL10−R(−3975) (P′ = 0.054). A full version of this table, contingency tables of the infection tests, and full results of Cox analyses for progression tests are listed at http://lgd.nci.nih.gov.
IL10, CCR2/CCR5, and STRL33 were analyzed with IL10−3975-R, IL10−1140-G, AFMB362WB9, GAAT12D11, and D3S2354, respectively.